趙寶國

1. 個人簡介：

姓名：趙寶國

職稱：教授

郵箱：zhaobg2006@shnu.edu.cn

簡介：趙寶國 (Dr. Baoguo Zhao) 博士，教授，博士生導師，有機化學專業。主要從事仿生不對稱催化和功能分子仿生合成的研究。

2. 教育工作經曆：

教育經曆：

   2003-2006，博士，中國科學院上海有機化學研究所

   1999-2002，碩士，南京大學

   1992-1996，學士，武漢大學

工作經曆：

 2011-至今，上海師範大學  教授

 2006-2011，美國科羅拉多州立大學  博士後

3. 研究領域：

 [1] 仿生不對稱催化

 [2] 仿生全合成

 [3]新反應發展

4. 成果：

代表性論文：

[1]Jianfeng Chen,^1,2‡ Xing Gong,^1‡ Jianyu Li,¹ Yingkun Li,¹ Jiguo Ma,¹ Chengkang Hou,¹ Guoqing Zhao,¹ Weicheng Yuan,^2*Baoguo Zhao^1* “Carbonyl Catalysis Enables a Biomimetic Asymmetric Mannich Reaction” Science2018, 360, 1438. (‡equally contributed).

[2]Jiguo Ma,^‡ Bin Gao,^‡ Guanshui Song, Ruixin Zhang, Qingfang Wang, Zi Ye, Wen-Wen Chen,* Baoguo Zhao* Asymmetric-Allylation of Glycinate with Switched Chemoselectivity Enabled by Customized Bifunctional Pyridoxal Catalysts. Angew. Chem., Int. Ed.2022, 10.1002/anie.202200850. (‡equally contributed).

[3]Bingfei Peng,^‡ Jiguo Ma,^‡ Jianhua Guo,^‡ Yating Gong, Ronghao Wang, Yi Zhang, Jinlong Zeng, Wen-Wen Chen,* Kuiling Ding,* Baoguo Zhao* A Powerful Chiral Super Brønsted C–H Acid for Asymmetric Catalysis. J. Am. Chem. Soc.2022, 144, 2853. (‡equally contributed).

[4]Aolin Cheng, Liangliang Zhang, Qinghai Zhou, Tao Liu, Jing Cao, Guoqing Zhao,* Kun Zhang, Guanshui Song, Baoguo Zhao* Efficient Asymmetric Biomimetic Aldol Reaction of Glycinates and Trifluoromethyl Ketones by Carbonyl Catalysis. Angew. Chem., Int. Ed.2021, 60, 20166.

[5]Jiguo Ma, Qinghai Zhou, Guanshui Song,Y ongchang Song, Guoqing Zhao, Kuiling Ding, Baoguo Zhao* Enantioselective Synthesis of Pyroglutamic Acid Esters from Glycinate via Carbonyl Catalysis. Angew. Chem., Int. Ed. 2021, 60, 10588.

[6]Weiqi Cai, Xuelong Qiao, Hao Zhang, Bo Li, Jianhua Guo, Liangliang Zhang, Wen-Wen Chen, Baoguo Zhao* Asymmetric biomimetic transamination of α-keto amides to peptides. Nat. Commun.2021, 12, 5174.

[7]Yong Ethan Liu, Zhaole Lu, Bo Li, Jiaxin Tian, Feng Liu, Junyu Zhao, Chengkang Hou, Yingkun Li, Lili Niu, Baoguo Zhao* “Enzyme-Inspired Axially Chiral Pyridoxamines Armed with a Cooperative Lateral Amine Chain for Enantioselective Biomimetic Transamination”J. Am. Chem. Soc. 2016, 138, 10730.

[8] Limin Shi, Chuangan Tao, Qin Yang, Yong Ethan Liu, Jing Chen, Jianfeng Chen, Jiaxin Tian, Feng Liu, Bo Li, Yongling Du, Baoguo Zhao* “Chiral Pyridoxal-Catalyzed Asymmetric Biomimetic Transamination of α-Keto Acids” Org. Lett.2015, 17, 5784.

[9]Lei Ding, Jing Chen, Yifan Hu, Juan Xu, Xing Gong, Dongfang Xu, Baoguo Zhao*, Hexing Li “Aminative Umpolung of Aldehydes to α-Amimo Anion Equivalents for Pd-catalyzed Allyation: An Efficient Synthesis of Homoallylic Amines” Org. Lett.2014, 16, 720.

[10]Baoguo Zhao, Zhaobin Han, Kuiling Ding* “N-H Functions in Organometallic Catalysis” Angew. Chem. Int. Ed.2013, 52, 4744.

代表性授權專利：

[1]趙寶國，劉勇，盧兆樂，李波，“一種手性聯芳骨架吡哆胺類催化劑及其合成方法與應用”，申請号：201610444057.X。

[2]趙寶國，陳劍鋒，趙濬宇，龔幸，“一種新型手性開鍊吡哆胺催化劑及其合成方法與應用”，專利号：201610444112.5。

[3]趙寶國，蘭曉宇，陶創安，劉旭亮，“一種手性吡哆胺催化劑及其合成方法和應用”，專利号：201610443128.4。

[4] 趙寶國，陳靜，石力敏，劉勇，楊琴，陳劍鋒，田家昕，陶創安，李波，許東芳“一種新型吡哆素衍生物及其制備方法”，專利号：201510413900.3。

[5] 趙寶國，陳靜，楊琴，陳劍鋒，石力敏，劉勇（Yong Ethan Liu），龔幸，蘭曉宇，盧兆樂，劉勇 (Yong Liu)，陶創安，田家昕，許東芳，“一種吡哆醛催化劑及其合成方法與應用”，專利号：201510415046.4。

[6] 趙寶國，陶創安，石力敏，劉勇，陳靜，“一種手性吡哆醛催化劑及其合成方法與應用”，專利号：201510427177.4。